SSGCID
Seattle Structural Genomics Center for Infectious Disease

Peer Reviewed Publications

Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis
Pierce PG, Hartnett B, Blain JM, Hagen TJ, Horn JR, Weiss MS, Myers J, Higgins T, Dranow DM, Sullivan A, Lorimer DD, Edwards TE, Myler PJ. Acta Crystallogr F Struct Biol Commun 80 Pt 2 (2024 Feb 1) 43-51.   PMID:38305785.   PMCID:PMC10836425.

Characterization of an Acinetobacter baumannii monofunctional phosphomethylpyrimidine kinase that is inhibited by pyridoxal phosphate
De Vitto H, Belfon KKJ, Toay S, Abendroth JA, Willis S, Barrera G, Beyer O, Li TD, Myler PJ, Hicks KA, Torelli AT, French JB, Dranow DM, Lorimer D, Edwards TE, Sharma N. Biochemistry   PMID:36475894.   PMCID:PMC9927488.

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
Lee J, Zepeda S, Park YJ, Taylor AL, Quispe J, Stewart C, Leaf EM, Treichel C, Corti D, King NP, Starr T, Veesler D. Cell Host Microbe 31 (12, 13 Dec 2023) 1961-1973.   PMID:37989312.   PMCID:pending.

Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila
Moorefield J, Konuk Y, Norman JO, Abendroth JA, Edwards TE, Lorimer DD, Mayclin SJ, Staker BL, Craig JC, Barrett LK, Barrett KF, Van Voorhis WC, Myler PJ, McLaughlin KJ. Acta Crystallogr F Struct Biol Commun (2023). F79 (Part 10) 257-266.   PMID:37728609.   PMCID:pending.

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
Kassu M, Parvatkar P, Milanes JE, Monaghan NP, Kim C, Dowgiallo M, Zhao Z, Asakawa A, Huang L, Wagner A, Miller B, Barrett KF, Tillery L, Barrett LK, Phan IQ, Subramanian S, Myler PJ, Van Voorhis WC, Leahy JW, Rice CA, Kyle D, Morris JC, Manetsch R. ACS Infect Dis (2023). 9(11) (2023 Nov 10) 2190-2201.   PMID:37820055.   PMCID:PMC10644346.

Identification of and structural insights into hit compounds targeting N-myristoyltranserase for Cryptosporidium drug development
Fenwick MK, Reers A, Liu Y, Zigweid R, Sankaran B, Shin J, Hulverson MA, Hammerson B, FernándezÁlvaro E, Myler PJ, Kaushansky A, Van Voorhis WC, Fan E, Staker BL. ACS Infect Dis (2023). 9 (10) 1821-1833.   PMID:37722671.   PMCID:10580320.

Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts
Rodriguez-Hernandez D, Vijayan K, Zigweid R, Fenwick MK, Sankaran B, Roobsoong W, Sattabongkot J, Glennon EKK, Myler PJ, Sunnerhagen P, Staker BL, Kaushansky A, Grotli M. Nat Commun (2023). 14 (2023 Sept 5) 5408.   PMID:37669940.   PMCID:PMC10480161.

Structure-guided discovery of N5-CAIR mutase inhibitors
Belfon KKJ, Sharma N, Tran N, Zigweid R, Bolejack M, Davies D, Myler PJ, French JB. Biochemistry 62 (17) 2587-2596.   PMID:37552766.   PMCID:PMC10484210.

Neutralization, effector function and immune imprinting of Omicron variants
Veesler D, Addetia A, Piccoli L, Case JB, Park YJ, Beltramello M, Guarino B, Dang HV, Pinto D, Scheaffer SM, Sprouse K, Bassi J, Silacci-Fregni C, Muoio F, Dini M, Vincenzetti L, Acosta R, Johnson D, Subramaniam S, Saliba Christian, Giurdanella M, Lombardo G, Leoni G, Culap K, McAlister C, Rajesh A, Dellota E, Cameroni E, Whitener B, Giannini O, Ceschi A, Ferrari P, Franzetti-Pellanda A, Biggiogero M, Garzoni C, Zappi S, Bernasconi L, Kim M, Schnell G, Czudnochowski N, Franko N, Logue J, Yoshiyama C, Stewart C, Chu H, Schmid M, Purcell LA, Snell G, Lanzavecchia A, Diamond M, Corti D. Nature   PMID:37648855.   PMCID:PMC10511321.

New therapeutic strategies for Mycobacterium abscessus pulmonary diseases - Untapping the mycolic acid pathway
Alcaraz M, Edwards TE, Kremer L. Expert Rev Anti Infect Ther (2022). 1-17.   PMID:37314394.   PMCID:PMC10529309.

Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail
Addetia A, Park YJ, Starr T, Greaney A, Sprouse K, Bowen J, Tiles SW, van Voorhis W, Bloom J, Corti D, Walls AC, Veesler D. Cell Regul. 42 (2023 June 27) 112621.   PMID:37300832.   PMCID:PMC10213294.

Bacterial Structural Genomics Target Enabled by Recently Discovered Potent Fungal ACS Inhibitor
DeBouver ND, Bolejack M, Esan TE, Krysan DJ, Hagen TJ, Abendroth J. Acta Crystallogr F Struct Biol Commun (2023). (79) 137-143.   PMID:37223974.   PMCID:PMC10231259.

Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site
Ghafoori SM, Peterson GF, Conrady DG, Calhoun BM, Stigliano M, Baydo RO, Grice RL, Abendroth J, Lorimer DD, Edwards TE, Forwood JK. Sci Rep 13 (1) 6940.   PMID:37117205.   PMCID:PMC10140725.

In vitro and in vivo efficacy of NITD-916 against Mycobacterium fortuitum
Roquet-Banères F, Alcaraz M, Hamela C, Abendroth J, Edwards TE, Kremer L. Antimicrob. Agents Chemother.   PMID:36920188.   PMCID:PMC10112203.

Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps
Muenks A, Zepeda S, Zhou G, Veesler D, DiMaio F. Nat Commun 14 (1) 1164.   PMID:PMC9976687.   PMCID:PMC9976687.

Drug-Repurposing Screening Identifies a Gallic Acid Binding Site on SARS-CoV-2 Nsp7
Gu Y, Liu M, Staker BL, Buchko GW, Quinn R. ACS Pharacol. Transl. Sci. (2023). 6 (4) 578-586.   PMID:37082753.   PMCID:PMC10111621.

A comparative study of eight serological methods shows that spike protein-based ELISAs are the most accurate tests for serodiagnosing SARS-CoV-2 infections in cats and dogs
Diezma-Diaz C, Alvarez-Garcia G, Regidor-Cerrillo J, Miro G, Villanueva-Saz S, Perez MD, Verde MT, Galan-Malo P, Brun A, Moreno S, Checa R, Montoya A, Ortega-Mora LM, Van Voorhis W. Front Vet Sci (2022). 10 (1121935)   PMID:36777670.   PMCID:PMC9909348.

Household Transmission of SARS-CoV-2 from Humans to Pets, Washington and Idaho, USA
Meisner J, Baszler TV, Kuehl KE, Ramirez V, Baines A, Frisbie LA, Lofgren ET, de Avila DM, Wolking RM, Bradway DS, Wilson HR, Lipton B, Kawakami V, Rabinowitz PM. Emerging Infect. Dis. (2022). 28 (December 2022) 2425-2424.   PMID:36288573.   PMCID:PMC9707573.

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Marzi R, Bassi J, Silacci-Fregni C, Bartha I, Muoio F, Culap K, Sprugasci N, Lombardo G, Saliba Christian, Cameroni E, Cassotta A, Low JS, Walls AC, McCallum M, Tortorici MA, Bowen J, Dellota E, Dillen J, Czudnochowski N, Pertusini L, Terrot T, Lepori V, Tarkowski M, Riva A, Biggiogero M, Franzetti-Pellanda A, Garzoni C, Ferrari P, Ceschi A, Giannini O, Havenar-Daughton C, Telenti A, Arvin A, Virgin HW, Sallusto F, Veesler D, Lanzavecchia A, Corti D, Piccoli L. [TBD]   PMID:36507220.   PMCID:PMC9721160.

SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines
Bowen J, Veesler D, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse K, McCallum M, Tortorici MA, Franko N, Logue J, Mazzitelli IG, Nguyen AW, Silva RP, Huang Y, Low JS, Jerak J, Tiles SW, Ahmed K, Shariq A, Dan JM, Zhang Z, Weiskopf D, Sette A, Snell G, Posavad CM, Iqbal NT, Geffner J, Bandera A, Gori A, Sallusto F, Maynard JA, Crotty S, van Voorhis W, Simmerling C, Grifantini R, Chu H, Corti D. Sci Immunol (2022). 78 (23 Dec 2022) eadf1421.   PMID:36356052.   PMCID:PMC9765460.

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Chen Y, Zhao H, Lan K, Corti D, Wang X, Yang H, Veesler D. Nature (2022). 7941 (2022 Dec) 748-757.   PMID:36477529.   PMCID:PMC9734910.

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains
Starr T, Greaney A, Stewart C, Walls AC, Hannon WW, Veesler D, Bloom J. PLoS Pathog. 11 (2022 Nov 18)   PMID:36399443.   PMCID:PMC9674177.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Park YJ, Pinto D, Walls AC, Liu Z, De Marco A, Benigni F, Zatta F, Silacci-Fregni C, Bassi J, Sprouse K, Addetia A, Bowen J, Stewart C, Giurdanella M, Saliba Christian, Guarino B, Schmid M, Franko N, Logue J, Dang HV, Hauser K, di Iulio J, Rivera W, Schnell G, Rajesh A, Zhou J, Farhat N, Kaiser H, Montiel_Ruiz M, Noack J, Lempp F, Janer J, Abdelnabi R, Maes P, Ferrari P, Ceschi A, Giannini O, de Melo GD, Kergoat L, Bourhy H, Neyts J, Soriaga L, Purcell LA, Snell G, Whelan SPJ, Lanzavecchia A, Virgin HW, Piccoli L, Chu H, Pizzuto M, Corti D, Veesler D. Science (2022). 378 (6620) 619-627.   PMID:35677069.   PMCID:PMC9176643.

Efficacy and mode of action of a direct inhibitor of Mycobacterium abscessus InhA
Alcaraz M, Roquet-Banères F, Leon-Icaza SA, Abendroth J, Boudehen Y-M, Cougoule C, Edwards TE, Kremer L. ACS Infect Dis   PMID:36107992.   PMCID:pending.

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development
Gihaz S, Gareiss P, Choi JY, Renard I, Pal AC, Surovsteva Y, Thekkiniath J, Plummer M, Fox D, Ojo KK, Staker BL, Fuller K, Ben Mamoun C. Structure (2022). 30 (11) 1494-1507.   PMID:36167065.   PMCID:10042587.

Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography
Maker A, Bolejack M, Schecterson L, Hammerson B, Staker B, Myler P, Gumbiner B. PNAS Nexus   PMID:36157596.   PMCID:PMC9491697.

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice
Walls AC, VanBlargan LA, Wu K, Choi A, Navarro M, Lee D, Avena L, Berrueta DM, Pham M, Elbashir S, Kraft J, Miranda M, Kepl E, Johnson M, Blackstone A, Sprouse K, Fiala B, O'Connor M, Brunette N, Arunachalam PS, Shirreff LM, Rogers K, Carter L, Fuller D, Villinger F, Pulendran B, Diamond M, Edwards DK, King NP, Veesler D. Cell Rep (2022). 40 (9) 111299.   PMID:35988541.   PMCID:PMC9376299.

Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody
Xie B, Maker A, Priest AV, Dranow DM, Phan JN, Edwards TE, Staker B, Myler PJ, Gumbiner B, Sivasankar S. Proc. Natl. Acad. Sci. U.S.A. (2022). 119 (32) e2204473119.   PMID:35921442.   PMCID:PMC9371698.

Crystal structures of glutamine-tRNA synthase from Elizabethkingia anopheles and E. meningosepticum
Brooks L, Subramanian S, Dranow DM, Mayclin SJ, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun (2022). 78 (Pt 8) 306-312.   PMID:35924598.   PMCID:PMC9350836.

Structural Characterization of Aspartate-Semialdehyde Dehydrogenase from Pseudomonas aeruginosa and Neisseria gonorrhoeae
Teakel S, Fairman JW, Abendroth J, Dranow DM, Muruthi MM, Lorimer DD, Edwards TE, Forwood JK. Sci Rep (2022). 12 (1) 14010.   PMID:35977963.   PMCID:PMC9385607.

Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine
Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye P, Golden N, Miranda M, Green K, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Adhikary NRD, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar M, Veesler D, Wang TT, King NP, Pulendran B. Sci Transl Med (2022). 14 (658) eabq4130.   PMID:35976993.   PMCID:pending.

Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
Bowen J, Addetia A, Dang HV, Stewart C, Brown JT, Sharkey WK, Sprouse K, Walls AC, Mazzitelli IG, Logue J, Franko N, Czudnochowski N, Powell AE, Dellota E, Ahmed K, Ansari AS, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Snell G, Grifantini R, Chu H, Veesler D. Science (2022).   PMID:35857529.   PMCID:PMC9348749.

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
Low JS, Jerak J, Tortorici MA, McCallum M, Pinto D, Cassotta A, Foglierini M, Mele F, Abdelnabi R, Weynand B, Noack J, Montiel_Ruiz M, Bianchi S, Benigni F, Sprugasci N, Joshi A, Bowen J, Stewart C, Rexhepaj M, Walls AC, Jarrossay D, Morone D, Paparoditis P, Garzoni C, Ferrari P, Ceschi A, Neyts J, Purcell LA, Snell G, Corti D, Lanzavecchia A, Veesler D, Sallusto F. Science (2022).   PMID:35857703.   PMCID:PMC9348755.

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution
Starr T, Greaney A, Hannon WW, Loes A, Hauser K, Dillen J, Ferri E, Farrel AG, Dadonaite B, McCallum M, Matreyek KA, Corti D, Veesler D, Snell G, Bloom J. Science (2022).   PMID:35762884.   PMCID:PMC9273037.

Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection
Alden KM, Jezewski AJ, Beattie SR, Fox D, Krysan DJ. MBio   PMID:35766403.   PMCID:PMC9426453.

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein
Tortorici MA, Walls AC, Joshi A, Park YJ, Eguia R, Miranda M, Kepl E, Dosey A, Stevens-Ayers T, Boeckh MJ, Telenti A, Lanzavecchia A, King NP, Corti D, Bloom J, Veesler D. Cell (2022). 185 (13) 2279-2291.   PMID:35700730.   PMCID:PMC9135795.

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
Malhi H, Homad LJ, Wan YH, Poudel B, Fiala B, Borst AJ, Wang J, Walkey C, Price J, Wall A, Singh S, Moodie Z, Carter L, Handa S, Correnti CE, Stoddard BL, Veesler D, Pancera M, Olson J, King NP, McGuire AT. Cell Rep (2022). 3 (6) 100658.   PMID:35705092.   PMCID:PMC9245003.

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus
Hoy M, Park E, Lee H, Lim WY, Cole D, DeBouver ND, Bobay B, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J. MBio (2022).   PMID:35604094.   PMCID:PMC9239059.

Characterization of glucokinases from pathogenic free-living amoebae
Milanes JE, Suryadi J, Monaghan NP, Harding EM, Morris CS, Rozema S, Khalifa MM, Golden JE, Phan IQ, Zigweid R, Abendroth JA, Rice CA, Wilson S, Fenwick MK, Morris JC. Antimicrob. Agents Chemother. (2022).   PMID:35604214.   PMCID:PMC9211422.

Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant
Wang Z, Dang HV, Amaya M, Xu Y, Yin R, Yan L, Hickey AC, Annand EJ, Horsburgh BA, Reid PA, Smith I, Eden JS, Xu K, Broder CC, Veesler D. PNAS Nexus (2022). 119 (22) e2122769119.   PMID:35617431.   PMCID:PMC9295758.

Structural Characterization of  Cytochrome c' Beta-Met from an Ammonia-Oxidizing Bacterium
Abendroth J, Buchko GW, Kim HJ, Liew F, Nguyen J. Biochemistry (2022). 61 (7) 563-574.   PMID:35315646.   PMCID:pending.

Design of protein-binding proteins from the target structure alone
Cao L, Coventry B, Goreshnik I, Huang B, Park JS, Jude K, Markovic I, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, DeWitt M, Picton L, Miller L, Strauch E, DeBouver ND, Halabiya S, Hammerson B, Yang W, Benard S, Stewart L, Wilson IA, Ruohola-Baker H, Schlessinger J, Lee S, Savvides SN, Garcia KC, Baker D. Nature   PMID:35332283.   PMCID:PMC9117152.

Expression and Structure of the Chlamydia trachomatis DksA Ortholog
Mandel C, Yang H, Buchko GW, Abendroth J, Grieshaber N, Chiarelli T, Grieshaber S, Omsland A. Pathog Dis (2022). 80 (1) ftac007.   PMID:35388904.   PMCID:PMC9126822.

Broad-spectrum Activity of Macrophage Infectivity Potentiator Inhibitors Against Gram-negative Bacteria and Leishmania major
Lorimer DD, Myler PJ, Sarkar-Tyson M, Harmer NJ, Norville IH, Holzgrabe U, Iwasaki J, Kibble EA, lewis m, Bzdyl N, Kristensen S, Seufert F, Schmitz J. J. Antimicrob. Chemother. (2022).   PMID:35245364.   PMCID:PMC9155639.

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx
Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA. Acta Crystallogr F Struct Biol Commun (2022). 78 (Pt 3) 135-142.   PMID:35234139.   PMCID:PMC8900733.

Architecture and antigenicity of the Nipah virus attachment glycoprotein
Wang Z, Amaya M, Addetia A, Dang HV, Reggiano G, Yan L, Hickey AC, DiMaio F, Broder CC, Veesler D. Science (2022). eabm5561.   PMID:35239409.   PMCID:pending.

Structural Characterization of a Cytochrome c-beta from an Ammonia-Oxidizing Bacterium
Abendroth J, Buchko GW, Liew F, Nguyen J, Kim HJ. Biochemistry (2022). 61 (7) 563-574.   PMID:35315646.   PMCID:pending.

Broad-spectrum in vitro activity of Macrophage Infectivity Potentiator Inhibitors against Gram-negative Bacteria and Leishmania major
Iwasaki J, Lorimer D, Vivoli M, Kibble EA, Peacock CS, Abendroth J, Mayclin SJ, Dranow D, Pierce PG, Fox D, lewis m, Bzdyl N, Kristensen S, Inglis TJJ, Kahler CM, Bond CB, Hasenkopf Anja, Seufert F, Schmitz J, Norville IH, Myler PJ, Holzgrabe U, Harmer NJ, Sarkar-Tyson M. J. Antimicrob. Chemother. (2022). 77 (6) 1625-1634.   PMID:35245364.   PMCID:PMC9155639.

Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei
Beard D, Subramanian S, Abendroth JA, Edwards TE, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun (2022). 78 (Pt 2) 45-51.   PMID:35102892.   PMCID:PMC8805214.

Crystal structure of a short chain dehydrogenase/reductase SDR from Burkholderia phymatum in complex with NAD
Alenazi J, Mayclin SJ, Subramanian S, Myler PJ, Asojo OA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2022). 78 (Pt 2) 52-58.   PMID:35102893.   PMCID:PMC8805215.

Structures of Plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme
Bhaumik P, Kesari P, Deshmukh A, Pahelkar N, Suryawanshi AB, Rathore I, Mishra V, Dupuis JH, Xiao H, Gustchina A, Abendroth J, Labaied M, Yada RY, Wlodawer A, Edwards T, Lorimer D. Protein Sci. (2022).   PMID:35048450.   PMCID:PMC8927862.

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
McCallum M, Czudnochowski N, Rosen L, Zepeda S, Bowen J, Dillen J, Powell AE, Croll TI, Nix J, Virgin HW, Corti D, Snell G, Veesler D. Science (2022). 375 (6583) 864-868.   PMID:35076256.   PMCID:PMC9427005.

Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans
Davidson J, Nicholas K, Conrady DG, Subramanian S, Mayclin SJ, Staker BL, Myler PJ, Asojo OA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2022). 78 (Pt 1) 25-30.   PMID:34981772.   PMCID:PMC8725002.

Crystal structure of a hypothetical protein from Giardia lamblia
Beard D, Bristol S, Crosby K, Davis A, Manning C, Perry L, Snapp L, Toy A, Wheeler K, Young J, Staker BL, Dranow DM, Abendroth JA, Edwards TE, Subramanian S, Asojo OA, Myler PJ. Acta Crystallogr F Struct Biol Commun (2022). 78 (Pt 2) 59-65.   PMID:35102894 .   PMCID:PMC8805217.
  -- Removed the EnhiA.00579.a ortholog structures :

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Park YJ, De Marco A, Starr T, Liu Z, Pinto D, Walls AC, Zatta F, Zepeda S, Bowen J, Sprouse K, Joshi A, Giurdanella M, Guarino B, Noack J, Abdelnabi R, Foo SYC, Lempp F, Benigni F, Snell G, Neyts J, Whelan SPJ, Virgin HW, Bloom J, Corti D, Pizzuto M, Veesler D. Science (2022). 375 (6579) 449-454.   PMID:34990214.   PMCID:PMC9400459.

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants
McCallum M, Walls AC, Sprouse K, Bowen J, Rosen L, Dang HV, De Marco A, Franko N, Tilles SW, Logue J, Miranda M, Ahlrichs M, Carter L, Snell G, Pizzuto M, Chu H, Van Voorhis W, Corti D, Veesler D. Science (2021). 374 (6575) 1621-1626.   PMID:34751595.   PMCID:pending.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Cameroni E, Bowen J, Rosen L, Saliba Christian, Zepeda S, Culap K, Pinto D, VanBlargan LA, De Marco A, di Iulio J, Zatta F, Kaiser H, Noack J, Farhat N, Czudnochowski N, Havenar-Daughton C, Sprouse K, Dillen J, Powell AE, Chen A, Maher C, Yin L, Sun D, Soriaga L, Bassi J, Silacci-Fregni C, Franko N, Logue J, Abdelnabi R, Chu H, Riva A, Giannini O, Ceschi A, Ferrari P, Cippa PE, Garzoni C, Kawaoka Y, Hebner CM, Piccoli L, Pizzuto M, Walls AC, Diamond M, Telenti A, Virgin HW, Lanzavecchia A, Snell G, Veesler D, Corti D. Nature (2022). 602 (7898) 664-670.   PMID:35016195.   PMCID:PMC9531318.

Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis
Porter I, Neal T, Walker Z, Hayes D, Thedford M, Fowler K, Billups N, Rhoades A, Smith C, Smith K, Staker BL, Dranow DM, Mayclin SJ, Subramanian S, Edwards TE, Myler PJ, Asojo OA. Acta Crystallogr F Struct Biol Commun (2022). 78 (Pt 1) 31-38.   PMID:34981773.   PMCID:PMC8725004.

Protein oligomer modeling guided by predicted inter-chain contacts in CASP14
Baek M, Anishchenko I, Park H, Humphreys IR, Baker D. Proteins (2021). 89 (12) 1824-1833.   PMID:34324224.   PMCID:PMC8616806.

Protein tertiary structure prediction and refinement using deep learning and Rosetta in CASP14
Anishchenko I, Baek M, Park H, Hiranuma N, Kim D, Dauparas J, Mansoor S, Humphreys IR, Baker D. Proteins (2021). 89 (12) 1722-1733.   PMID:34331359.   PMCID:PMC8616808.

SARS-CoV-2 infection in one cat and three dogs living in COVID-19-positive households in Madrid, Spain
Miro G, Regidor-Cerrillo J, Checa R, Diezma-Diaz C, Montoya A, Garcia-Cantalejo J, Botias P, Arroyo J, Ortega-Mora LM. Front Vet Sci (2021). 8 779341.   PMID:34901253.   PMCID:PMC8660077.

The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
Phan IQ, Rice CA, Craig JC, Noorai R, McDonald J, Subramanian S, Tillery L, Barrett LK, Shankar V, Morris JC, Van Voorhis WC, Kyle D, Myler PJ. Sci Rep (2021). 11 (1) 21664.   PMID:34737367.   PMCID:PMC8569187.

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Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice
Demars A, Vitali A, Comein A, Carlier E, Azouz A, Goriely S, Smout J, Flamand V, Van Gysel M, Wouters J, Abendroth J, Edwards T, Machelart A, Hoffmann E, Brodin P, De Bolle X, Muraille E. PLoS Pathog. (2021). 17 (9)   PMID:34525130.   PMCID:PMC8443048.

Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module
Schirmer T, de Beer T, Tamegger S, Harms A, Dietz N, Dranow D, Edwards T, Myler P, Phan I, Dehio C. Microorganisms (2021). 9 (8) 1645.   PMID:34442725.   PMCID:PMC8401265.

Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases
Jezewski AJ, Alden KM, Esan TE, DeBouver ND, Abendroth J, Bullen J, Calhoun BM, Potts KT, Murante D, Hagen TJ, Fox D, Krysan DJ. ACS Chem. Biol. (2021). 16 (8) 1587-1599.   PMID:34369755.   PMCID:PMC8383264.

Multivalent designed proteins protect against SARS-CoV-2 variants of concern and confer protection against infection in mice
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Broad sarbecovirus neutralization by a human monoclonal antibody
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SARS-CoV-2 immune evasion by the variant B.1.427/B.1.429 variant of concern
McCallum M, Bassi J, De Marco A, Chen A, Walls AC, di Iulio J, Tortorici MA, Navarro M, Silacci-Fregni C, Saliba Christian, Agostini M, Pinto D, Culap K, Bianchi S, Jaconi S, Cameroni E, Bowen J, Tilles SW, Pizzuto M, Guastalla SB, Bona G, Pellanda A, Garzoni C, Van Voorhis WC, Rosen L, Snell G, Telenti A, Virgin HW, Piccoli L, Corti D, Veesler D. Science (2021).   PMID:34210893.   PMCID:PMC8020983.

Host-targeted interventions as an exciting opportunity to combat malaria
Vijayan K, Wei L, Glennon EKK, Mattocks C, Bourgeois N, Staker BL, Kaushansky A. [TBD] (2021). 121 (17) 10452-10468.   PMID:34197083.   PMCID:pending.

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design
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Structural basis for broad coronavirus neutralization
Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad LJ, Acton O, Bowen J, Wang C, Xiong X, de van der Schueren W, Quispe J, King NP, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Nat. Struct. Mol. Biol. (2021). 82 (6) 478-486.   PMID:33981021.   PMCID:pending.

Structural characterization of Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1
Ghafoori SM, Dranow DM, Mayclin SJ, Lorimer DD, Edwards TE, Shirmast P, Forwood JK. Sci Rep (2021). 11 (1) 9453.   PMID:33947893.   PMCID:PMC8096840.

High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
Choi R, Zhou M, Shek R, Wilson JW, Tillery L, Craig JC, Salukhe IA, James RM, Buchko GW. PLoS ONE (2021). 16 (4) e0250019.   PMID:33886614.   PMCID:PMC8062000.

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
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Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
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Functional Analysis of the Fusion and Attachment Glycoproteins of Mojiang Henipavirus
Da Silva SC, Yan L, Dang HV, Xu K, Epstein JH, Veesler D, Broder CC. Viruses (2021). 13 (3) 517.   PMID:33809833.   PMCID:PMC8004131.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
McCallum M, De Marco A, Lempp F, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen J, Ruiz M, Zhou J, Rosen L, Bianchi S, Guarino B, Silacci-Fregni C, Abdelnabi R, Foo SYC, Rothlauf PW, Veesler D. Cell (2021). 184 (9) 2332-2347.   PMID:33761326.   PMCID:PMC7962585.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates
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Sensitivity of SARS-CoV-2 B. 1.1. 7 to mRNA vaccine-elicited antibodies
Collier DA, De Marco A, Ferreira IATM, Meng B, Datir R, Walls AC, Kemp SA, Bassi J, Pinto D, Silacci-Fregni C, Bianchi S, Tortorici MA, Bowen J, Culap K, Jaconi S, Cameroni E, Snell G, Pizzuto M, Pellanda A. Nature (2021). 593 (7857) 136-141.   PMID:33706364.   PMCID:pending.

Quadrivalent influenza nanoparticle vaccines induce broad protection
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton O, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L. Nature (2021). 592 (7855) 623-628.   PMID:33762730.   PMCID:PMC8269962.

Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis
Rodarte JV, Abendroth JA, Edwards TE, Lorimer DD, Lukacs CM, Davies DR, Staker BL, Zhang S, Myler PJ, McLaughlin KJ. Acta Crystallogr F Struct Biol Commun (2021). 77 (Pt 2) 54-60.   PMID:33620038.   PMCID:PMC7900926.

In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
Phan IQ, Subramanian S, Kim D, Murphy M, Pettie D, Carter L, Anishchenko I, Barrett LK, Craig JC, Tillery L, Shek R, Harrington W, Koelle D, Wald A, Veesler D, King NP, Boonyaratanakornkit J, Isoherranen N, Greninger A, Jerome K, Chu H, Staker BL, Stewart LJ, Myler PJ, Van Voorhis WC. Sci Rep (2021). 11 (1) 4290.   PMID:33619344.   PMCID:PMC7900118.

Chromatin-associated protein complexes provide a link between DNA base J and transcription termination in Leishmania
Jensen BC, Phan IQ, McDonald J, Sur A, Gillespie MA, Ranish JA, Parsons M, Myler PJ. mSphere (2021). 6 (1) e01204-20.   PMID:33627513.   PMCID:PMC8544896.

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Barrett KF, Tillery L, Goldstein J, Lassner JW, Osterhout B, Tran N, Xu L, Young RM, Craig JC, Chun IKH, Dranow DM, Abendroth J, Staker B, Subramanian S, Phan IQ, Myler PJ, Edwards TE, Kyle D, Rice CA, Morris JC, Leahy JW, Manetsch R, Barrett LK, Smith C, Van Voorhis WC. PLoS ONE (2021). 16 (3) e0241738.   PMID:33760815.   PMCID:PMC7990177.

Enzymatic and structural characterization of the Naegleria fowleri glucokinase
Milanes JE, Suryadi J, Abendroth J, Van Voorhis W, Barrett KF, Dranow DM, Phan IQ, Patrick SL, Rozema S, Khalifa MM, Golden JE, Morris JC. Antimicrob. Agents Chemother. (2019). 63 (5) e02410-18.   PMID:30783001.   PMCID:PMC6496100.

Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface
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Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms - us) dynamics in the C-terminal helix at the dimer interface
Buchko GW, Zhou M, Craig JC, Van Voorhis WC, Myler PJ. Biomol NMR Assign (2021). 15 (1) 107-116.   PMID:33392924.   PMCID:PMC7779335.

Broadly neutralizing antibody cocktails targeting the Nipah virus and Hendra virus fusion glycoproteins
Dang HV, Cross R, Borisevich V, Bornholdt ZA, West BR, Chan YP, Mire CE, Da Silva SC, Dimitrov AS, Yan L, Amaya M, Navaratnarajah CK, Zeitlin L, Geisbert T, Broder CC, Veesler D. Nat. Struct. Mol. Biol. (2021). 28 (5) 426-434.   PMID:33927387.   PMCID:pending.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
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De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
Baker D, Diamond M, Stewart L, Park YJ, Walls AC, Carter L, Chen R, Kozodoy L, Miller L, Case JB, Coventry B, Goreshnik I, Cao L. Science (2020). 370 (6515) 426-431.   PMID:32907861.   PMCID:PMC7857403.

Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR
Riboldi GP, Zigweid R, Myler PJ, Mayclin SJ, Counago R, Staker B. RSC Med Chem. (2021). 12 (1) 103-109.   PMID:34046602.   PMCID:PMC8130613.
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Structural analysis of CACHE domain of the McpA chemoreceptor from Leptospira interrogans
Santos JC, Vieira M, Abendroth J, Lin T, Staker B, Myler P, Nascimento A. Biochem. Biophys. Res. Commun. (2020).   PMID:33097187.   PMCID:PMC7744396.

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection
Mire CE, Chan YP, Borisevich V, Cross R, Yan L, Agans K, Dang HV, Veesler D, Fenton K, Geisbert T, Broder CC. J. Infect. Dis. (2019). 221 (2020 May 11) S471-S479.   PMID: 31686101.   PMCID:PMC7199785.

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
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Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Wall A, Beltramello M, Silacci-Fregni C, Pinto D, Rosen L, Bowen J, Acton O, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix J, Mele F, Jovic S, Rodriguez B, Gupta S, Jin F, Piumatti G, Presti G, Pellanda A, Biggiogero M, Tarkowski M, Pizzuto M, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D. Cell (2020). 183 (4) 1024-1042.e21.   PMID:32991844.   PMCID:PMC7494283.

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes
Patel SM, Smith TG, Morton M, Stiers KM, Seravalli J, Mayclin SJ, Edwards TE, Tanner JJ, Becker DF. Biochemistry (2020). 59 (36) 3285-3289.   PMID:32841567.   PMCID:PMC8528484.

Seroprevalence of SARS-CoV-2 among children visiting a hospital during the initial Seattle outbreak
Dingens A, Crawford K, Adler A, Steele S, Lacombe K, Eguia R, Amanat F, Walls AC, Wolf C, Murphy M, Pettie D, Carter L, Qin X, King NP, Krammer F, Chu H, Englund J, Bloom J. Nat Commun (2020). 11 (4378)   PMID:32873791.   PMCID:PMC7463158.

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
Starr T, Greaney A, Hilton S, Ellis D, Crawford K, Dingens A, Navarro M, Bowen J, Tortorici MA, Walls AC, King NP, Veesler D, Bloom J. Cell (2020). 182 (5) 1295-1310.e20.   PMID:32841599.   PMCID:PMC7418704.

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
Erasmus J, Khandhar A, Walls AC, Hemann E, O'Connor M, Murapa P, Archer J, Leventhal S, Fuller J, Lewis T, Draves K, Randall S, Guerriero K, Duthie M, Carter D, Reed S, Hawman D, Feldmann H, Gale M, Veesler D, Berglund P, Fuller D. Sci Transl Med (2020). 12 (5555) eabc9396.   PMID:32690628.   PMCID:PMC7402629.

NMR structure of Dengue West Nile viruses stem-loop B: A key cisacting element for flavivirus replication
Sharma S. Biochem. Biophys. Res. Commun. (2020). 531 (4) 522-527.   PMID:32807496.   PMCID:PMC7494574.

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
McCallum M, Walls AC, Corti D, Bowen J. Nat. Struct. Mol. Biol. (2020). 27 (10) 942-949.   PMID:32753755.   PMCID:PMC7541350.

HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction
Ianiri G, Coelho M, Ruchti F, Sparber F, McMahon TJ, Fu C, Bolejack M, Donovan O, Smutney H, Dietrich FS, Myler PJ, Fox D, LeibundGut-Landmann S, Heitman J. Proc. Natl. Acad. Sci. U.S.A. (2020). 117 (27) 15884-15894.   PMID:32576698.   PMCID:PMC7354939.

Discovery of a natural product that binds to the Mycobacterium tuberculosis protein Rv1466 using native mass spectrometry
Elnaas A, Grice D, Han J, Feng YR, Di Capua A, Mak T, Laureanti J, Buchko GW, Myler PJ, Cook G, Quinn RJ, Liu M. Molecules (2020). 25 (10) 2385.   PMID:32455540.   PMCID:PMC7288112 .

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Park YJ, Walls AC, Pinto D, Beltramello M, Tortorici MA, Bianchi S, Jaconi S, Culap K, Zatta F, De Marco A, Peter A, Guarino B, Spreafico R, Cameroni E, Case JB, Havenar-Daughton C, Snell G, Telenti A, Virgin HW, Lanzavecchia A, Diamond M, Fink K, Corti D. Nature (2020). 583 (7815) 290-295.   PMID:32422645.   PMCID:pending.

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
Crawford K, Eguia R, Dingens A, Loes A, Malone K, Wolf C, Chu H, Tortorici MA, Veesler D, Murphy M, Pettie D, King NP, Balazs A, Bloom J. Viruses (2020). 12 (5) 513.   PMID:32384820.   PMCID:PMC7291041.

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
McCormack K, Dranow DM, Smutney H, Bullen J, Abendroth JA. ACS Med Chem Lett (2020). 11 (6) 1160-1167.   PMID:32550996.   PMCID:PMC7294737.

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Cell (2020). 181 (2) 281-292.e6.   PMID:32155444.   PMCID:PMC7102599.

A phenotarget approach for identifying an alkaloid interacting with the tuberculosis protein Rv1466
Xie Y, Feng Y, Di Capua A, Mak T, Buchko GW, Myler PJ, Liu M, Quinn RJ. Mar Drugs (2020). 18 (3) 149.   PMID:32150903.   PMCID:PMC7143284.

A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers
Leung J, Nagayasu E, Hwang Y-C, Liu J, Pierce PG, Phan IQ, Stacy R, Murray J, Hu K. BMC Biol. (2020). 21 (1) 8.   PMID:32111164.   PMCID:PMC7048138.

Comparative structure, dynamics and evolution of acyl-carrier proteins from Borrelia burgdorferi, Brucella melitensis and Rickettsia prowazekii
Barnwal RP, Gartia J, Varani G, Kuar M, Heckert A. Biochem. J. (2020). 477 (2) 491-508.   PMID:31922183.   PMCID:PMC7878103.

Structures of glyceraldehyde 3-phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis
Barrett KF, Dranow DM, Phan I, Michaels SA, Shaheen S, Navaluna ED, Craig JC, Tillery L, Choi R, Edwards TE, Conrady DG, Abendroth J, Horanyi PS, Lorimer DD, Van Voorhis WC, Zhang Z, Barrett LK, Subramanian S, Staker B, Fan E, Myler P, Soge OO, Hybiske K, Ojo KK. Protein Sci. (2020). 29 (3) 768-778.   PMID:31930578.   PMCID:PMC7020975.

Towards a structome of Acinetobacter baumannii drug targets
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Crystal structure of a hemerythrin-like protein from Mycobacterium kansasii and homology model of the orthologous Rv2633c protein of M. tuberculosis
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Solution structure for an Encephalitozoon cuniculi adrenodoxin‐like protein in the oxidized state
Shaheen S, Barrett KF, Subramanian S, Arnold SLM, Laureanti J, Myler PJ, Van Voorhis WC, Buchko GW. Protein Sci. (2020). 29 (3) 809-817.   PMID:31912584.   PMCID:PMC7020980.

Identification of selective inhibitors of Plasmodium N-myristoyltransferase by high throughput screening
Harupa A, De Las Heras L, Colmenarejo G, Lyons-Abbott S, Reers A, Caballero I, Chung CW, Charter D, Myler PJ, Fernández-Menéndez R, Calderón F, Palomo S, Rodríguez-Miquel B, Berlanga M, Herreros-Avilés E, Staker BL, Fernández-Álvaro E, Kaushansky A. J. Med. Chem. (2020). 63 (2) 591-600.   PMID:31850752.   PMCID:pending.

Glutaminyl-tRNA synthetase from Pseudomonas aeruginosa: Characterization, Structure, and Development as a Screening Platform
Escamilla Y, Hughes CA, Abendroth J, Dranow DM, Balboa S, Dean F, Bullard JM. Protein Sci. (2019). 29 (4) 905-918.   PMID:31833153.   PMCID:PMC7096721.

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D. Nat. Struct. Mol. Biol. (2019). 26 (12) 1151-1157.   PMID:31792450.   PMCID:PMC7097669 .

Structural diversity in the mycobacteria DUF3349 superfamily
Buchko GW, Abendroth J, Robinson JI, Phan I, Myler PJ, Edwards TE. Protein Sci. (2020). 29 (3) 670-685.   PMID:31658388.   PMCID:PMC7020984.

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.
Dang HV, Chan YP, Park YJ, Snijder J, Vu B, Yan L, Feng YR, Rockx B, Giesbert T, Mire CE, Broder CC, Veesler D. Nat. Struct. Mol. Biol. (2019). 26 (30 September 2019) 980-987.   PMID:31570878.   PMCID:PMC6858553.

Integrated target‐based and phenotypic screening approaches for the identification of anti‐tubercular agents that bind to the mycobacterial adenylating enzyme MbtA
Ferguson L, Bhakta S, Wells G, Johnson J, Prentice RA, Guzman J, Parish T, Brucoli F. ChemMedChem (2019). 14 (19) 1735-1741.   PMID:31454170 .   PMCID:PMC6800809.

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Juvvadi PR, Fox D, Bobay B, Hoy M, Gobeil S, Venters R, Chang Z, Lin J, Averette A, Cole D, Barrington B, Wheaton J, Ciofani M, Trzoss M, Li X, Lee S, Chen Y, Mutz M, Spicer L, Schumacher M, Heitman J, Steinbach W. Nat Commun (2019). 10 4275.   PMID:31537789.   PMCID:PMC6753081.

Protein Interaction networks revealed by proteome co-evolution
Cong Q, Anishchenko I, Ovchinnikov S, Baker D. Science (2019). 365 (6449) 185-189.   PMID:31296772.   PMCID:PMC6948103.

The domain architecture of JBP1 suggests synergy between J-base DNA binding and thymidine hydroxylase activity
Heidebrecht T, Adamopoulos A, Roosendaal J, Touw WG, Phan IQ, Beijnen J, Perrakis A. J. Biol. Chem. (2019).   PMID:31292194.   PMCID:PMC6709619.

Structural characterization of β‐ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites
Patterson E, Nanson J, Abendroth JA, Bryan CM, Sankaran B, Myler PJ, Forwood JK. Proteins (2019). 88 (1) 47-56.   PMID:31237717.   PMCID:PMC9518911.

Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands
Clifton MC, Rupert PB, Hoette TM, Raymond KN, Abergel RJ, Strong RK. J. Struct. Biol. (2019). 2 100008.   PMID:32647813.   PMCID:PMC7337064.

Optimization of methionyl tRNA-synthetase inhibitors for treatment of Cryptosporidium infection
Buckner F, Ranade RM, Gillespie J, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WG, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Jumani RS, Huston CD, Fan E. Antimicrob. Agents Chemother. (2019). 63 (4) pii: e02061-18.   PMID:30745384.   PMCID:PMC6437504.

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Lore K, Perez L, King NP. Cell (2019). 176 (6) 1420-1431.   PMID:30849373.   PMCID:PMC6424820 .

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors
Schlott A, Mayclin SJ, Reers A, Coburn-Flynn O, Bell A, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker B, Chung CW, Myler P, Fidock DA, Tate E, Holder A. Cell Chem Biol (2019). S2451-9456 (19) 30111-4.   PMID:31080074.   PMCID:PMC6437504.

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products
Sullivan A, Dranow DM, Horanyi PS, Lorimer DD, Edwards TE, Abendroth J. Sci Rep (2019). 9 4392.   PMID:30867460.   PMCID:PMC6416309.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Baragana B, Forte B, Choi R, Nakazawa-Hewitt S, Bueren-Calabuig J, Pisco JP, Peet C, Norcross N, Jansen C, Robinson DA, Anderson M, Brooks CF, Cooper CA, Damerow S, Dowers K, Dranow DM, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jimenez-Diaz B, Jumani RS, Lorimer DD, Love M, Maher S, Matthews H, McNamarra C, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Tamaki FK, Tamar J, Torrie LS, Vantaux A, Vinayak S, Witkowski B, Wittlin S, Zuccotto F, Angulo-Barturen IA, Sinden R, Baum J, Gamo F-J, Maser P, Kyle D, Winzeler E, Myler PJ, Willis P, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov A, Walpole C, Read KD, Van Voorhis WC, Gilbert IH. Proc. Natl. Acad. Sci. U.S.A. (2019).   PMID:30894487 .   PMCID:PMC6452685.

Characterization and structure determination of prolyl-tRNA synthetase from Pseudomonas aeruginosa and development as a screening platform
Pena N, Dranow DM, Hu Y, Escamilla Y, Bullard JM. Protein Sci. (2019).   PMID:30666738 .   PMCID:PMC6423717.

Unexpected receptor functional mimicry elucidates activation of coronavirus fusion
Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quisp J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D. Cell (2019). 176 (5) 1026-1039.   PMID:30712865.   PMCID:PMC6751136.

Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy
Park YJ, Lacourse KD, Cambillau C, DiMaio F, Mougous JD, Veesler D. Nat Commun (2018). 9 (1) 5385.   PMID:30568167.   PMCID:PMC6300606.

Using MbtH-like proteins to alter substrate profile of a nonribosomal peptide adenylation enzyme
Mori S, Green K, Choi R, Buchko GW, Fried M, Garneau-Tsodikova S. Chembiochem (2018). 19 (20) 2186-2194.   PMID:30134012.   PMCID:PMC6439349.

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO
Abendroth J, Sankaran B, Myler PJ, Lorimer DD, Edwards TE. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2018). F74 530-535.   PMID:30198884.   PMCID:PMC6130419.

Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides
Buchko GW, Pulavarti SVSRK, Ovchinnikov V, Shaw E, Rettie SA, Myler PJ, Karplus M, Szyperski T, Baker D, Bahl CD. Protein Sci. (2018). 27 (9) 1611-1623.   PMID:30152054.   PMCID:PMC6194292.

Structure and analysis of Nucleoside Diphosphate Kinase from Borellia burgdoferi prepared in transition state complex with ADP and vanadate moieties
Dumais M, Davies DR, Lin T, Staker BL, Myler PJ, Van Voorhis WC. Acta Crystallogr F Struct Biol Commun (2018). F74 373-84.   PMID:29870023 .   PMCID:PMC5987747.

The Identification of Inhibitory Compounds of Rickettsia prowazekii Methionine Aminopeptidase for Antibacterial Applications
Helgren TR, Seven E, Chen C, Edwards TE, Staker BL, Abendroth JA, Myler PJ, Horn JR, Hagen TJ. Bioorg. Med. Chem. Lett. (2018). 28 1376-1380.   PMID:29551481.   PMCID:PMC5908248.

Crystal structure of Chorismate mutase from Burkholderia phymatum
Asojo OA, Subramanian S, Abendroth JA, Exley I, Lorimer DD, Edwards TE, Myler PJ. Acta Crystallogr F Struct Biol Commun (2018). 74 187-192.   PMID:29633965.   PMCID:PMC5894103.

An antibody targeting the fusion machinery neutralizes dual-tropic infection and defines a site of vulnerability on Epstein-Barr virus
Snijder J, Ortego MS, Weidle C, Stuart AB, Gray MA, McElrath MJ, Pancera M, Veesler D, McGuire AT. Immunity (2018).   PMID:29669253.   PMCID:PMC5909843.

Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics
Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ. Acta Crystallogr F Struct Biol Commun (2018). F74 (1) 46-56.   PMID:29372907.   PMCID:PMC5947692.

Crystal Structure of Chorismate Mutase from Burkholderia thailandensis
Asojo OA, Dranow DM, Serbzhinskiy D, Subramanian S, Staker B, Edwards TE, Myler PJ. Acta Crystallogr F Struct Biol Commun (2018). 74 294-299.   PMID:29717997.   PMCID:PMC5931142.

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein
Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C. Protein Sci. (2018). 27 (2) 568-572.   PMID:29119630.   PMCID:PMC5775179.

Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections
Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, McGuire AT, Rey FA, Bosch BJ, Veesler D. J. Virol. (2017). 92 (4) e01628-17.   PMID:29093093 .   PMCID:PMC5790929.

Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA
Buchko GW, Echols N, Flynn EM, Ng H-L, Stephenson S, Kim H, Myler PJ, Terwilliger TC, Alber T, Kim CY. Biochemistry (2017). 56 (30) 4015-1027.   PMID:28692281.   PMCID:pending.

Functional characterisation of Burkholderia pseudomallei biotin protein ligase: A toolkit for anti-melioidosis drug development
Bond T, Sorenson AE, Schaeffer P. Microbiol. Res. (2017). 199 40-48.   PMID:28454708.   PMCID:pending.

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii
Long S, Brown KM, Drewry LL, Anthony B, Phan IQ, Sibley D. PLoS Pathog. (2017). 5 (13) 5.   PMID:28475612.   PMCID:PMC5435356.

Structure of acid deoxyribonuclease
Varela-Ramirez A, Abendroth J, Mejia AA, Phan IQ, Lorimer D, Edwards TE, Aguilera R. Nucleic Acids Res. (2017). 45 (10) 6217-6227.   PMID:28369538.   PMCID:PMC5449587.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
Moen S, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD. Sci Rep (2017). 7 (1) 223.   PMID:28303005.   PMCID:PMC5428304.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors
Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE. Sci Rep (2017). 7 41074.   PMID:28120876.   PMCID:PMC5264612.

Structural basis for the strict substrate selectivity of the mycobacterial hydrolase LipW
McKary MG, Abendroth J, Edwards TE, Johnson RJ. Biochemistry (2016). 55 (51) 7099-7111.   PMID:27936614.   PMCID:PMC5482207.

Backbone chemical shift assignments and secondary structure analysis of the U1 protein from the Bas-Congo virus
Buchko GW, Clifton MC, Wallace E, Atkins K, Myler PJ. Biomol NMR Assign (2017). 11 (1) 51-56.   PMID:27981424.   PMCID:PMC8457264.

The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 A resolution
Cala A, Nadeau M, Abendroth J, Staker B, Reers A, Weatherhead A, Dobson R, Myler P, Hudson AO. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2016). 72 (12) 886-891.   PMID:27917836.   PMCID:PMC5137465.

Rickettsia prowazekii Methionine Aminopeptidase as a Promising Target for the Development of Antibacterial Agents
Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth JA, Sankaran B, Housley NA, Myler PJ, Audia J, Horn JR, Hagen TJ. Bioorg. Med. Chem. (2017). 16 ( ) S0968-0896.   PMID:28089350.   PMCID:PMC5319851.

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1
Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngo H, Gubbels MJ. Mol. Microbiol. (2016). 103 (4) 618-634.   PMID:27859784.   PMCID: 5296235.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Nakazawa Hewitt S, Dranow DM, Horst B, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragana B, Choi R, Rivas K, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Gray DW, Read KD, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC. ACS Infect Dis (2017). 3 (1) 34-44.   PMID:27798837.   PMCID:27798837.

The BID domain of type IV secretion substrates forms a conserved four-helix bundle topped with a hook
Stanger F, de Beer T, Dranow D, Schirmer T, Phan I, Dehio C. Structure (2017). 25 (1) 203-211.   PMID:27889208.   PMCID:PMC6121808.
  -- Recommended by Faculty of 1000 : https://f1000.com/prime/727033390

Brucella melitensis methionyl-tRNA-synthetase (MetRS), a potential drug target for brucellosis
Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers J, Choi R, Nakazawa-Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner F, Fan E, Van Voorhis WC. PLoS ONE (2016). 11 (8) e0160350.   PMID:27500735.   PMCID:PMC4976878.

Accurate de novo design of hyperstable constrained peptides
Bhardwaj J, Mulligan VK, Bahl CD, Gilmore JM, Harvey P, Cheneval O, Buchko GW, Pulavarti SVSRK, Kaas Q, Eletsky A, Huang PS, Griesen P, Johnsen WA, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D. Nature (2016). 538 (7625) 329-335.   PMID:27626386.   PMCID:PMC5161715.

Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis
Barnwal RP, Loh E, Godin KS, Yip J, Lavender H, Varani G, Tang C. Nucleic Acids Res. (2016).   PMID:27369378.   PMCID:PMC5100586.

The Rickettsia type IV secretion system: unrealized complexity mired by gene family expansion
Gillespie J, Phan I, Driscoll TP, Guilotte ML, Lehman SS, Rennoll-Bankert KE, Subramanian S, Beier-Sexton M, Myler PJ, Sayeedur Rahman M, Azad AF. Pathog Dis (2016). 74 (6) ftw058.   PMID:27307105.   PMCID:PMC5505475.
  -- Editors Choice : http://femspd.oxfordjournals.org/content/74/6/ftw058

Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target
Craig JC, Risler JK, Loesch K, Dong W, Subramanian S, Samudrala R, Van Voorhis WC, Baker D, Barrett LK. J Biomol Screen (2016). 21 (7) 695-700.   PMID:27146385.   PMCID:PMC8565994.

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 A resolution
Naqvi KF, Staker BL, Dobson RCJ, Serbzhinisky D, Sankaran B, Myler PJ, Hudson AO. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 1 (72) 2-9.   PMID:26750477.   PMCID:PMC4708043.

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.
Gillespie J, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Sayeedur Rahman M, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen A. MBio (2015). 6 (6) e01867-15.   PMID:26646013.   PMCID:PMC4676284.
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Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.
Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ. Bioorg. Med. Chem. Lett. (2015). Dec 15 (24) 5699-5704.   PMID:26584881.   PMCID:PMC4764408.

An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum.
Olivia Chavez AS, Fairman JW, Felsheim RF, Nelson CM, Herron MJ, Higgins L, Burkhardt NY, Oliver JD, Markowski TW, Kurtti TJ, Edwards TE, Munderloh UG. PLoS Pathog. (2015). 11 (11) e1005248.   PMID:26544981.   PMCID:PMC4636158.

Recent contributions of structure-based drug design to the development of antibacterial compounds
Staker BL, Buchko GW, Myler PJ. Curr. Opin. Microbiol. (2015). 27 133-8.   PMID:26458180.   PMCID:PMC4659754.

Advances in Bacterial Methionine Aminopeptidase Inhibition.
Helgren TR, Wangtrakuldee P, Staker BL, Hagen TJ. Curr Top Med Chem (2015). 16 (4) 397-414.   PMID:26268344.   PMCID:PMC5009474.

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.
Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 572-6.   PMID:25945711.   PMCID:PMC4427167.

Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface.
Buchko GW, Edwards TE, Hewitt SN, Phan IQ, Van Voorhis WC, Miller SI, Myler PJ. Biomol NMR Assign (2015). 9 (2) 381-5.   PMID:25957069.   PMCID:PMC4569509.

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.
Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 615-21.   PMID:25961325.   PMCID:PMC4427173.

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.
Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 609-14.   PMID:25945716.   PMCID:PMC4361283.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.
Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD. J. Struct. Funct. Genomics (2015). 16 (2) 91-9.   PMID:25832174.   PMCID:PMC4631608.

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.
Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 594-9.   PMID:25945714.   PMCID:PMC4427170.

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.
Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO. J. Infect. Dis. (2015). 212 Suppl 2 S167-71.   PMID:25957961.   PMCID:PMC4564533.

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.
Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, van Voorhis W, Myler P, Lorimer DD, Edwards TE. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 566-71.   PMID:25945710.   PMCID:PMC4427166.

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.
Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2015). 71 (Pt 5) 560-5.   PMID:25945709.   PMCID:PMC4427165.

Targeting Influenza A Virus RNA Promoter
Bottini A, De SK, Wu B, Varani G, Pellecchia M, Tang C. Chem Biol Drug Des (2015). 86 (4) 663-73.   PMID:25676805.   PMCID:PMC4531110.

Crystal Structure of a CutA1 Divalent ion Tolerance Protein from Cryptosporidium Parvum, the Protozoal Parasite Responsible for Cryptosporidiosis
Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2014). 71 (Pt 5) 522-30.   PMID:25945704.   PMCID:PMC4427160.

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.
Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2014). 71 (Pt 5) 514-21.   PMID:25945703.   PMCID:PMC4427159.

Increasing the structural coverage of tuberculosis drug targets.
Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ. Tuberculosis (Edinb) (2014). 95 (2) 142-8.   PMID:25613812.   PMCID:PMC4361283.
  -- Author presentation of results : http://www.tuberculosisjournal.com/article/S1472-9792(14)20565-8/abstract
  -- Explore the Mtb-NTM-PDB network : https://www.ssgcid.org/publication/mtb-ntm-pdb-network/

Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate.
Moreno MA, Alonso A, Alcolea PJ, Abramov A, de Lacoba MG, Abendroth J, Zhang S, Edwards T, Lorimer D, Myler PJ, Larraga V. Int. J. Parasitol. (2014). 4 (3) 347-54.   PMID:25516846.   PMCID:PMC4266777.

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.
Moen SO, Abendroth J, Fairman JW, Baydo RO, Bullen J, Kirkwood JL, Barnes SR, Raymond AC, Begley DW, Henkel G, McCormack K, Tam VC, Phan I, Staker BL, Stacy R, Myler PJ, Lorimer D, Edwards TE. Sci Rep (2014). 4 (4) 5944.   PMID:25089892.   PMCID:PMC4123200.

Structure of tyrosine aminotransferase from Leishmania infantum.
Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2014). 70 (Pt 5) 583-7.   PMID:24817714.   PMCID:PMC4014323.

Structure of the Reston ebolavirus VP30 C-terminal domain.
Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2014). 70 (Pt 4) 457-60.   PMID:24699737.   PMCID:PMC3976061.

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Linford AS, Jiang NM, Edwards TE, Sherman NE, Van Voorhis WC, Stewart LJ, Myler PJ, Staker BL, Petri WA. Mol. Biochem. Parasitol. (2014). 193 (1) 33-44.   PMID:24548880.   PMCID:PMC4022148.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Begley DW, Fox D, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD. Antimicrob. Agents Chemother. (2013). 58 (3) 1458-67.   PMID:24366729.   PMCID:PMC3957879.

Solution structure of a putative FKBP-type peptidyl-propyl cis-trans isomerase from Giardia lamblia.
Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ. J. Biomol. NMR (2013). 57 (4) 369-74.   PMID:24293257.   PMCID:PMC3903135.

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.
Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C. J. Biol. Chem. (2013). 289 (4) 2139-47.   PMID:24311791.   PMCID:PMC3900960.

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Lee MK, Bottini A, Kim M, Bardaro MF, Zhang Z, Pellecchia M, Choi BS, Varani G. Chem. Commun. (Camb.) (2013). 50 (3) 368-70.   PMID:24247110.   PMCID:PMC3894927.

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.
Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Bioorg. Med. Chem. Lett. (2013). 23 (24) 6860-3.   PMID:24157367.   PMCID:PMC3874807.

The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force.
Bocedi A, Fabrini R, Farrotti A, Stella L, Ketterman AJ, Pedersen JZ, Allocati N, Lau PC, Grosse S, Eltis LD, Ruzzini A, Edwards TE, Morici L, Del Grosso E, Guidoni L, Bovi D, Lo Bello M, Federici G, Parker MW, Board PG, Ricci G. J. Biol. Chem. (2013). 288 (34) 24936-47.   PMID:23828197.   PMCID:PMC3750189.

Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity.
Wangtrakuldee P, Byrd MS, Campos CG, Henderson MW, Zhang Z, Clare M, Masoudi A, Myler PJ, Horn JR, Cotter PA, Hagen TJ. ACS Med Chem Lett (2013). 4 (8) 669-703.   PMID:24376907.   PMCID:PMC3871185.

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.
Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, Van Voorhis WC, Myler PJ. J. Struct. Funct. Genomics (2013). 14 (2) 47-57.   PMID:23709284.   PMCID:PMC3826599.

Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D.
Zhang Y, Gardberg AS, Edwards TE, Sankaran B, Robinson H, Varnum SM, Buchko GW. Biochimie (2013). 95 (7) 1379-85.   PMID:23523511.   PMCID:PMC3674139.

Combining functional and structural genomics to sample the essential Burkholderia structome.
Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC. PLoS ONE (2012). 8 (1) e53851.   PMID:23382856.   PMCID:PMC3561365.
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Learning virulent proteins from integrated query networks.
Cadag E, Tarczy-Hornoch P, Myler PJ. BMC Bioinformatics (2012). 13 321.   PMID:23198735.   PMCID:PMC3560104.

Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins.
Leibly DJ, Nguyen TN, Kao LT, Hewitt SN, Barrett LK, Van Voorhis WC. PLoS ONE (2012). 7 (12) e52482.   PMID:23285060.   PMCID:PMC3527557.
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Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.
Armour BL, Barnes SR, Moen SO, Smith E, Raymond AC, Fairman JW, Stewart LJ, Staker BL, Begley DW, Edwards TE, Lorimer DD. J Vis Exp (2013). Jun 28 (76)   PMID:23851357.   PMCID:PMC3747311.

Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines.
Correnti C, Richardson V, Sia AK, Bandaranayake AD, Ruiz M, Suryo Rahmanto Y, Kovacevic Ž, Clifton MC, Holmes MA, Kaiser BK, Barasch J, Raymond KN, Richardson DR, Strong RK. PLoS ONE (2012). 7 (8) e43696.   PMID:22928018.   PMCID:PMC3424236.

Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.
Edwards TE, Liao R, Phan I, Myler PJ, Grundner C. Protein Sci. (2012). 21 (7) 1093-6.   PMID:22544630.   PMCID:PMC3403447.

Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.
Edwards TE, Abramov AB, Smith ER, Baydo RO, Leonard JT, Leibly DJ, Thompkins KB, Clifton MC, Gardberg AS, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. BMC Struct. Biol. (2011). 11 39.   PMID:21995815.   PMCID:PMC3212906.

Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.
Yates SP, Edwards TE, Bryan CM, Stein AJ, Van Voorhis WC, Myler PJ, Stewart LJ, Zheng J, Jia Z. Biochemistry (2011). 50 (38) 8103-6.   PMID:21870819.   PMCID:PMC3354702.

Wheat germ cell-free expression system as a pathway to improve protein yield and solubility for the SSGCID pipeline.
Guild K, Zhang Y, Stacy R, Mundt E, Benbow S, Green A, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1027-31.   PMID:21904045.   PMCID:PMC3169397.
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Structure of aldose reductase from Giardia lamblia.
Ferrell M, Abendroth J, Zhang Y, Sankaran B, Edwards TE, Staker BL, Van Voorhis WC, Stewart LJ, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1113-7.   PMID:21904059.   PMCID:PMC3169411.
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Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 A resolution.
Subramanian S, Abendroth J, Phan IQ, Olsen C, Staker BL, Napuli A, Van Voorhis WC, Stacy R, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1118-22.   PMID:21904060.   PMCID:PMC3169412.
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An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.
Davies DR, Staker BL, Abendroth JA, Edwards TE, Hartley R, Leonard J, Kim H, Rychel AL, Hewitt SN, Myler PJ, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1044-50.   PMID:21904048.   PMCID:PMC3169400.
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Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans.
Clifton MC, Abendroth J, Edwards TE, Leibly DJ, Gillespie AK, Ferrell M, Dieterich SH, Exley I, Staker BL, Myler PJ, Van Voorhis WC, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1154-8.   PMID:21904066.   PMCID:PMC3169418.
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Structural genomics of infectious disease drug targets: the SSGCID.
Stacy R, Begley DW, Phan I, Staker BL, Van Voorhis WC, Varani G, Buchko GW, Stewart LJ, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 979-84.   PMID:21904037.   PMCID:PMC3169389.
  -- Complete SSGCID Special Issue : http://journals.iucr.org/f/issues/2011/09/00/index.html

The Protein Maker: an automated system for high-throughput parallel purification.
Smith ER, Begley DW, Anderson V, Raymond AC, Haffner TE, Robinson JI, Edwards TE, Duncan N, Gerdts CJ, Mixon MB, Nollert P, Staker BL, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1015-21.   PMID:21904043.   PMCID:PMC3169395.
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Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
Begley DW, Edwards TE, Raymond AC, Smith ER, Hartley RC, Abendroth J, Sankaran B, Lorimer DD, Myler PJ, Staker BL, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1070-7.   PMID:21904052.   PMCID:PMC3169404.
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Salvage and storage of infectious disease protein targets in the SSGCID high-throughput crystallization pathway using microfluidics.
Christensen J, Gerdts CJ, Clifton MC, Stewart L. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1022-6.   PMID:21904044.   PMCID:PMC3169396.
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Gene Composer in a structural genomics environment.
Lorimer D, Raymond A, Mixon M, Burgin A, Staker B, Stewart L. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 985-91.   PMID:21904038.   PMCID:PMC3169390.
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Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria.
Phan I, Subramanian S, Olsen C, Edwards TE, Guo W, Zhang Y, Van Voorhis WC, Stewart LJ, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1123-8.   PMID:21904061.   PMCID:PMC3169413.
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Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease.
Raymond A, Haffner T, Ng N, Lorimer D, Staker B, Stewart L. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 992-7.   PMID:21904039.   PMCID:PMC3169391.
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Chemical shift assignments for Rv0577, a putative glyoxylase associated with virulence from Mycobacterium tuberculosis
Buchko GW, Kim H, Myler PJ, Terwilliger TC, Kim CY. Biomol NMR Assign (2011). 6 (1) 43-6.   PMID:21761124.   PMCID:PMC3374633.

Expression of proteins in Escherichia coli as fusions with maltose-binding protein to rescue non-expressed targets in a high-throughput protein-expression and purification pipeline.
Hewitt SN, Choi R, Kelley A, Crowther GJ, Napuli AJ, Van Voorhis WC. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1006-9.   PMID:21904041.   PMCID:PMC3169393.
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Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi.
Gardberg A, Sankaran B, Davies D, Bhandari J, Staker B, Stewart L. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1055-9.   PMID:21904050.   PMCID:PMC3169402.
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Structure of triosephosphate isomerase from Cryptosporidium parvum.
Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1095-9.   PMID:21904056.   PMCID:PMC3169408.
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Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1, 6-bisphosphate
Gardberg A, Abendroth J, Bhandari J, Sankaran B, Staker B. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1051-4.   PMID:21904049.   PMCID:PMC3169401.
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The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.
Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ. Biochem. J. (2011). 437 (3) 413-22.   PMID:21574961.   PMCID:PMC4045482.

High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease.
Bryan CM, Bhandari J, Napuli AJ, Leibly DJ, Choi R, Kelley A, Van Voorhis WC, Edwards TE, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1010-4.   PMID:21904042.   PMCID:PMC3169394.
  -- Complete SSGCID Special Issue : http://journals.iucr.org/f/issues/2011/09/00/index.html

Structure of a cyclin-dependent kinase from Giardia lamblia.
Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, van Voorhis W. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1084-9.   PMID:21904054.   PMCID:PMC3169406.
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Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success.
Choi R, Kelley A, Leibly D, Hewitt SN, Napuli A, van Voorhis W. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 998-1005.   PMID:21904040.   PMCID:PMC3169392.
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Structure of thymidylate kinase from Ehrlichia chaffeensis.
Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1090-4.   PMID:21904055.   PMCID:PMC3169407.
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Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile.
Zhang Y, Edwards TE, Begley DW, Abramov A, Thompkins KB, Ferrell M, Guo WJ, Phan I, Olsen C, Napuli A, Sankaran B, Stacy R, Van Voorhis WC, Stewart LJ, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1100-5.   PMID:21904057.   PMCID:PMC3169409.
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Comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens.
Leeper T, Zhang S, Van Voorhis WC, Myler PJ, Varani G. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1141-7.   PMID:21904064.   PMCID:PMC3169416.
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Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.
Buchko GW, Edwards TE, Abendroth J, Arakaki TL, Law L, Napuli AJ, Hewitt SN, Van Voorhis WC, Stewart LJ, Staker BL, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1078-83.   PMID:21904053.   PMCID:PMC3169405.
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BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative beta-lactamase-like protein' from Brucella melitensis.
Abendroth J, Sankaran B, Edwards TE, Gardberg AS, Dieterich S, Bhandari J, Napuli AJ, Van Voorhis WC, Staker BL, Myler PJ, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1106-12.   PMID:21904058.   PMCID:PMC3169410.
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Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.
Edwards TE, Bryan CM, Leibly DJ, Dieterich SH, Abendroth J, Sankaran B, Sivam D, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1038-43.   PMID:21904047.   PMCID:PMC3169399.

Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.
Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS. J. Biol. Chem. (2011). 286 (17) 15298-307.   PMID:21383008.   PMCID:PMC3083160.

SAD phasing using iodide ions in a high-throughput structural genomics environment.
Abendroth J, Gardberg AS, Robinson JI, Christensen JS, Staker BL, Myler PJ, Stewart LJ, Edwards TE. J. Struct. Funct. Genomics (2011). 12 (2) 83-95.   PMID:21359836.   PMCID:PMC3123459.

Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.
Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1129-36.   PMID:21904062.   PMCID:PMC3169414.
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Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. J. Struct. Funct. Genomics (2011). 12 (2) 63-76.   PMID:21359640.   PMCID:PMC3123455.

NMR structure of an acyl-carrier protein from Borrelia burgdorferi.
Barnwal RP, Van Voorhis WC, Varani G. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1137-40.   PMID:21904063.   PMCID:PMC3169415.
  -- Complete SSGCID Special Issue : http://journals.iucr.org/f/issues/2011/09/00/index.html

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei.
Edwards TE, Leibly DJ, Bhandari J, Statnekov JB, Phan I, Dieterich SH, Abendroth J, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1032-7.   PMID:21904046.   PMCID:PMC3169398.
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Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2011). 67 (Pt 9) 1148-53.   PMID:21904065.   PMCID:PMC3169417.
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Inaugural structure from the DUF3349 superfamily of proteins, Mycobacterium tuberculosis Rv0543c.
Buchko GW, Phan I, Myler PJ, Terwilliger TC, Kim CY. Arch. Biochem. Biophys. (2010). 506 (2) 150-6.   PMID:21144816.   PMCID:PMC3035944.

Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions.
Zhang Y, Buchko GW, Qin L, Robinson H, Varnum SM. Biochem. Biophys. Res. Commun. (2010). 404 (1) 407-12.   PMID:21130733.   PMCID:PMC3019264.

Design and initial characterization of the SC-200 proteomics standard mixture.
Bauman A, Higdon R, Rapson S, Loiue B, Hogan J, Stacy R, Napuli A, Guo W, van Voorhis W, Roach J, Lu V, Landorf E, Stewart E, Kolker N, Collart F, Myler P, van Belle G, Kolker E. OMICS (2010). 15 (1-2) 73-82.   PMID:21250827.   PMCID:PMC3110723.

Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head.
Edwards TE, Phan I, Abendroth J, Dieterich SH, Masoudi A, Guo W, Hewitt SN, Kelley A, Leibly D, Brittnacher MJ, Staker BL, Miller SI, Van Voorhis WC, Myler PJ, Stewart LJ. PLoS ONE (2010). 5 (9) e12803.   PMID:20862217.   PMCID:PMC2942831.

Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system.
Gerdts CJ, Stahl GL, Napuli A, Staker B, Abendroth J, Edwards TE, Myler P, van Voorhis W, Nollert P, Stewart LJ. J Appl Crystallogr (2010). 43 (Pt 5) 1078-1083.   PMID:22477778.   PMCID:PMC3263815.

Biological and structural characterization of a host-adapting amino acid in influenza virus.
Yamada S, Hatta M, Staker BL, Watanabe S, Imai M, Shinya K, Sakai-Tagawa Y, Ito M, Ozawa M, Watanabe T, Sakabe S, Li C, Kim JH, Myler PJ, Phan I, Raymond A, Smith E, Stacy R, Nidom CA, Lank SM, Wiseman RW, Bimber BN, O'Connor DH, Neumann G, Stewart LJ, Kawaoka Y. PLoS Pathog. (2010). 6 (8) e1001034.   PMID:20700447.   PMCID:PMC2916879.

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening.
Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (2010). 67 (Pt 9) 1060-9.   PMID:21904051.   PMCID:PMC3169403.
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Solution structure of Rv2377c-founding member of the MbtH-like protein family.
Buchko GW, Kim CY, Terwilliger TC, Myler PJ. Tuberculosis (Edinb) (2010). 90 (4) 245-51.   PMID:20434955.   PMCID:PMC2910232.

Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the ''open'' state.
Buchko GW, Robinson H, Abendroth J, Staker BL, Myler PJ. Biochem. Biophys. Res. Commun. (2010). 394 (4) 1012-7.   PMID:20331978.   PMCID:PMC2856777.

X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
Abendroth J, McCormick MS, Edwards TE, Staker B, Loewen R, Gifford M, Rifkin J, Mayer C, Guo W, Zhang Y, Myler P, Kelley A, Analau E, Hewitt SN, Napuli AJ, Kuhn P, Ruth RD, Stewart LJ. J. Struct. Funct. Genomics (2010). 11 (1) 91-100.   PMID:20364333.   PMCID:PMC2939714.

The role of medical structural genomics in discovering new drugs for infectious diseases.
Van Voorhis WC, Hol WG, Myler PJ, Stewart LJ. PLoS Comput. Biol. (2009). 5 (10) e1000530.   PMID:19855826.   PMCID:PMC2756625.

Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei.
Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ. Biomol NMR Assign (2009). 3 (2) 163-6.   PMID:19888681.   PMCID:PMC2774895.

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
Raymond A, Lovell S, Lorimer D, Walchli J, Mixon M, Wallace E, Thompkins K, Archer K, Burgin A, Stewart L. BMC Biotechnol. (2009). 9 (Apr 21) 37.   PMID:19383143.   PMCID:PMC2680836.

The Seattle Structural Genomics Center for Infectious Disease (SSGCID).
Myler PJ, Stacy R, Stewart L, Staker BL, Van Voorhis WC, Varani G, Buchko GW. Infect Disord Drug Targets (2009). 9 (5) 493-506.   PMID:19594426.   PMCID:PMC2857597.

The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS).
Gerdts CJ, Elliott M, Lovell S, Mixon MB, Napuli AJ, Staker BL, Nollert P, Stewart L. Acta Crystallogr. D Biol. Crystallogr. (2008). 64 (Pt 11) 1116-22.   PMID:19020349.   PMCID:PMC2585160.