Researchers from Seattle Structural Genomics Center for Infectious Diseases (SSGCID) have determined the three-dimensional protein structure for Mycobacterium tuberculosis protein Rv0543c, a member of the DUF3349 protein superfamily. This protein is highly conserved in M. tuberculosis and other Mycobacterium and Rhodococcus species and the structure is the first determined for the DIF3349 superfamily. Rv0543c is a 100 residue, 11.3 kDa protein that both size exclusion chromatography and NMR spectroscopy show to be a monomer in solution. As shown in accompanying figure, the structure of the protein consists of a bundle of five α-helices rigidly held together by a largely conserved group of hydrophobic amino acid side chains.
For more information, please see the Protein Data Bank entry 2KVC. This work is accepted for publication in Archives of Biochemistry and Biophysics.
From our own @davefox3rd - HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin i… https://t.co/EcMBsMUshp
6 months ago
The University of Washington’s Institute for Protein Design has become a hub to galvanize de novo protein engineeri… https://t.co/aqFbeqLkXO
7 months ago
Our study of the S309 SARS-CoV-2 neutralizing antibody is featured in the @sfchronicle (thank you @CDizikes). Clini… https://t.co/bbMILL2rtB
7 months, 1 week ago